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370026 Acute myeloid leukemia with t(8;16)(p11;p13) translocation

definition

Acute myeloid leukemia (AML) with (8;16)(p11;p13) translocation is a distinct form of AML in which this chromosomal anomaly is found de novo or in therapy-related AML cases, and is characterized by frequent extramedullary involvement (mainly hepatomegaly, splenomegaly, lymphadenopathies, cutaneous infiltration, but also gum, bone, central nervous system, testicles involvement), severe coagulation disorder (disseminated intravascular coagulopathy or primary fibrinolysis) and poor prognosis. Morphologically, a blast population with a myelomonocytic stage of differentiation is observed.