Mucolipidosis III gamma (ML 3 gamma) is a very rare lysosomal disease, that has most often been observed in the Middle East, characterized by a progressive slowing of the growth rate in early childhood; stiffness and pain in shoulders, hips, and finger joints; a gradual, mild coarsening of facial features; and by a slower progression, milder clinical course and longer life expectancy than that seen in mucolipidosis II and mucolipidosis III alpha/beta (see these terms). Cognitive function is normal or only slightly impaired and retinitis pigmentosa (see this term) has been reported in a few patients. Many survive into early adulthood, but ultimately succumb to cardiorespiratory insufficiency.